Liver X receptor alpha ensures blood-brain barrier function by suppressing SNAI2

Liver X receptor alpha ensures blood-brain barrier function by suppressing SNAI2

Abstract In Alzheimer’s disease (AD) more than 50% of the patients are affected by capillary cerebral amyloid-angiopathy (capCAA), which is characterized by localized hypoxia, neuro-inflammation and loss of blood-brain barrier (BBB) function. Moreover, AD patients with or without capCAA display incr...

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Bibliographic Details
Main Authors: D. Vacondio, H. Nogueira Pinto, L. Coenen, I. A. Mulder, R. Fontijn, B. van het Hof, W. K. Fung, A. Jongejan, G. Kooij, N. Zelcer, A. J. Rozemuller, H. E. de Vries, N. M. de Wit
Format: Article
Language:English
Published: Nature Publishing Group 2023-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06316-8

Internet

https://doi.org/10.1038/s41419-023-06316-8

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