In vitro hypoxia responsiveness of [18F] FDG and [18F] FAZA retention: influence of shaking versus stagnant conditions, glass versus polystyrene substrata and cell number down-scaling

In vitro hypoxia responsiveness of [18F] FDG and [18F] FAZA retention: influence of shaking versus stagnant conditions, glass versus polystyrene substrata and cell number down-scaling

Abstract Background In vitro experiments using radiolabeled molecules is fundamental for Positron emission tomography (PET) or single photon emission computed tomography (SPECT) tracer development and various metabolic assays, but no consensus on appropriate incubation conditions exists. Specificall...

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Bibliographic Details
Main Authors: Morten Busk, Michael R. Horsman, Jens Overgaard, Steen Jakobsen
Format: Article
Language:English
Published: SpringerOpen 2020-06-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Hypoxia
Tracer availability
Diffusion
Convection
Cell substrata
In vitro conditions
Online Access:http://link.springer.com/article/10.1186/s41181-020-00099-5

Internet

http://link.springer.com/article/10.1186/s41181-020-00099-5

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