Exploiting Manipulated Small Extracellular Vesicles to Subvert Immunosuppression at the Tumor Microenvironment through Mannose Receptor/CD206 Targeting

Exploiting Manipulated Small Extracellular Vesicles to Subvert Immunosuppression at the Tumor Microenvironment through Mannose Receptor/CD206 Targeting

Immunosuppression at tumor microenvironment (TME) is one of the major obstacles to be overcome for an effective therapeutic intervention against solid tumors. Tumor-associated macrophages (TAMs) comprise a sub-population that plays multiple pro-tumoral roles in tumor development including general im...

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Bibliographic Details
Main Authors: Maria Luisa Fiani, Valeria Barreca, Massimo Sargiacomo, Flavia Ferrantelli, Francesco Manfredi, Maurizio Federico
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:International Journal of Molecular Sciences
Subjects:
tumor-associated macrophages
tumor microenvironment
macrophage polarization
mannose receptor
exosomes
extracellular vesicles
Online Access:https://www.mdpi.com/1422-0067/21/17/6318

Internet

https://www.mdpi.com/1422-0067/21/17/6318

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