Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice

Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice

Abstract Purpose Prostatitis is a highly prevalent condition that seriously affects men’s physical and mental health. Although epidemiological investigations have provided evidence of a correlation between insufficient sleep and prostatitis, the pathogenesis of prostatitis remains unclear. We sought...

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Bibliographic Details
Main Authors: Jia Chen, Wenming Ma, Shaoyu Yue, Dongsheng Li, Lei Chen, Cheng Zhang, Yu Guan, Chun Li, Changqin Jiang, Guiyi Liao, Chaozhao Liang, Hui Wang, Sheng Tai
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cell Communication and Signaling
Subjects:
Sleep deprivation
Melatonin
Dihydrotestosterone
cGAS-STING
Prostatitis
Online Access:https://doi.org/10.1186/s12964-024-01554-5

Internet

https://doi.org/10.1186/s12964-024-01554-5

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