Cellular senescence and metabolic reprogramming model based on bulk/single-cell RNA sequencing reveals PTGER4 as a therapeutic target for ccRCC

Cellular senescence and metabolic reprogramming model based on bulk/single-cell RNA sequencing reveals PTGER4 as a therapeutic target for ccRCC

Abstract Clear cell renal cell carcinoma (ccRCC) is the prevailing histological subtype of renal cell carcinoma and has unique metabolic reprogramming during its occurrence and development. Cell senescence is one of the newly identified tumor characteristics. However, there is a dearth of methodical...

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Bibliographic Details
Main Authors: Lijie Zhou, Youmiao Zeng, Yuanhao Liu, Kaixuan Du, Yongbo Luo, Yiheng Dai, Wenbang Pan, Lailai Zhang, Lei Zhang, Fengyan Tian, Chaohui Gu
Format: Article
Language:English
Published: BMC 2024-04-01
Series:BMC Cancer
Subjects:
Renal cell carcinoma
Cellular senescence
Metabolism
PTGER4
Online Access:https://doi.org/10.1186/s12885-024-12234-5

Internet

https://doi.org/10.1186/s12885-024-12234-5

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