Carotenoids present in goji berries Lycium barbarum L. are suitable to protect against mycotoxins effects: An in vitro study of bioavailability
Bioactive compounds (BACs) in natural matrices are compartmented in specific anatomical structures resulting in low bioavailability. Here the study of bioavailability of carotenoids presents in Lycium barbarum L. goji berries (GB): zeaxanthin dipalmitate (ZDP), lutein (LUT), and zeaxanthin (ZEAX) us...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-05-01
|
| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464622001190 |
| _version_ | 1828280622654685184 |
|---|---|
| author | Cristina Juan Domenico Montesano Jordi Mañes Ana Juan-García |
| author_facet | Cristina Juan Domenico Montesano Jordi Mañes Ana Juan-García |
| author_sort | Cristina Juan |
| collection | DOAJ |
| description | Bioactive compounds (BACs) in natural matrices are compartmented in specific anatomical structures resulting in low bioavailability. Here the study of bioavailability of carotenoids presents in Lycium barbarum L. goji berries (GB): zeaxanthin dipalmitate (ZDP), lutein (LUT), and zeaxanthin (ZEAX) using a trans-epithelial model with Caco-2 cells are presented. Among that the potential cytoprotection ZDP against beauvericin (BEA) mycotoxin in HepG2 cells was also carried out. Results revealed that the percentage of carotenoids from digested GB oscillated between 40 % and 98 % from 1 h to 4 h in differentiated Caco-2 cells for the most bioavailable carotenoids: LUT, ZEAX, and ZDP. The bioavailability of standard carotenoids at different concentrations was lower than those from natural digested GB. The disposition of GB carotenoids according to their bioavailability corresponds to ZDP > ZEAX > LUT. Cytoprotection of ZDP against beauvericin (BEA) in pretreatment strategy in HepG2 cells increased with the exposure time (from 24 h to 48 h) and the dose (BEA 1.25 µM to 2.5 µM); while in simultaneous, a decrease was observed with the time and an increase with the dose. |
| first_indexed | 2024-04-13T08:02:14Z |
| format | Article |
| id | doaj.art-32ea764295844f4caeed995acbff6331 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-04-13T08:02:14Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-32ea764295844f4caeed995acbff63312022-12-22T02:55:15ZengElsevierJournal of Functional Foods1756-46462022-05-0192105049Carotenoids present in goji berries Lycium barbarum L. are suitable to protect against mycotoxins effects: An in vitro study of bioavailabilityCristina Juan0Domenico Montesano1Jordi Mañes2Ana Juan-García3Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, València, SpainDepartment of Pharmacy, University of Naples Federico II, via D. Montesano, 49 – 80131, Naples, ItalyLaboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, València, SpainLaboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, University of Valencia, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, València, Spain; Corresponding author.Bioactive compounds (BACs) in natural matrices are compartmented in specific anatomical structures resulting in low bioavailability. Here the study of bioavailability of carotenoids presents in Lycium barbarum L. goji berries (GB): zeaxanthin dipalmitate (ZDP), lutein (LUT), and zeaxanthin (ZEAX) using a trans-epithelial model with Caco-2 cells are presented. Among that the potential cytoprotection ZDP against beauvericin (BEA) mycotoxin in HepG2 cells was also carried out. Results revealed that the percentage of carotenoids from digested GB oscillated between 40 % and 98 % from 1 h to 4 h in differentiated Caco-2 cells for the most bioavailable carotenoids: LUT, ZEAX, and ZDP. The bioavailability of standard carotenoids at different concentrations was lower than those from natural digested GB. The disposition of GB carotenoids according to their bioavailability corresponds to ZDP > ZEAX > LUT. Cytoprotection of ZDP against beauvericin (BEA) in pretreatment strategy in HepG2 cells increased with the exposure time (from 24 h to 48 h) and the dose (BEA 1.25 µM to 2.5 µM); while in simultaneous, a decrease was observed with the time and an increase with the dose.http://www.sciencedirect.com/science/article/pii/S1756464622001190Goji berryBioavailabilityCarotenoidsCytoprotection |
| spellingShingle | Cristina Juan Domenico Montesano Jordi Mañes Ana Juan-García Carotenoids present in goji berries Lycium barbarum L. are suitable to protect against mycotoxins effects: An in vitro study of bioavailability Journal of Functional Foods Goji berry Bioavailability Carotenoids Cytoprotection |
| title | Carotenoids present in goji berries Lycium barbarum L. are suitable to protect against mycotoxins effects: An in vitro study of bioavailability |
| title_full | Carotenoids present in goji berries Lycium barbarum L. are suitable to protect against mycotoxins effects: An in vitro study of bioavailability |
| title_fullStr | Carotenoids present in goji berries Lycium barbarum L. are suitable to protect against mycotoxins effects: An in vitro study of bioavailability |
| title_full_unstemmed | Carotenoids present in goji berries Lycium barbarum L. are suitable to protect against mycotoxins effects: An in vitro study of bioavailability |
| title_short | Carotenoids present in goji berries Lycium barbarum L. are suitable to protect against mycotoxins effects: An in vitro study of bioavailability |
| title_sort | carotenoids present in goji berries lycium barbarum l are suitable to protect against mycotoxins effects an in vitro study of bioavailability |
| topic | Goji berry Bioavailability Carotenoids Cytoprotection |
| url | http://www.sciencedirect.com/science/article/pii/S1756464622001190 |
| work_keys_str_mv | AT cristinajuan carotenoidspresentingojiberrieslyciumbarbarumlaresuitabletoprotectagainstmycotoxinseffectsaninvitrostudyofbioavailability AT domenicomontesano carotenoidspresentingojiberrieslyciumbarbarumlaresuitabletoprotectagainstmycotoxinseffectsaninvitrostudyofbioavailability AT jordimanes carotenoidspresentingojiberrieslyciumbarbarumlaresuitabletoprotectagainstmycotoxinseffectsaninvitrostudyofbioavailability AT anajuangarcia carotenoidspresentingojiberrieslyciumbarbarumlaresuitabletoprotectagainstmycotoxinseffectsaninvitrostudyofbioavailability |