From the PnTx2-6 Toxin to the PnPP-19 Engineered Peptide: Therapeutic Potential in Erectile Dysfunction, Nociception, and Glaucoma

From the PnTx2-6 Toxin to the PnPP-19 Engineered Peptide: Therapeutic Potential in Erectile Dysfunction, Nociception, and Glaucoma

The venom of the “armed” spider Phoneutria nigriventer comprises several potent toxins. One of the most toxic components from this venom is the neurotoxin PnTx2-6 (LD50 = ∼ 0.7 μg/mouse, 48 residues, five disulfide bridges, MW = 5,289.31 Da), which slows down the inactivation of various Na+ channels...

Full description

Bibliographic Details
Main Authors: Carolina Nunes da Silva, Kenia Pedrosa Nunes, Lays Fernanda Nunes Dourado, Thayllon Oliveira Vieira, Xavier Maia Mariano, Armando da Silva Cunha Junior, Maria Elena de Lima
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Molecular Biosciences
Subjects:
PnTx2-6
PnPP-19
erectile dysfunction
glaucoma
pain
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2022.831823/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2022.831823/full

Similar Items