Top-Down Clustering for Protein Subfamily Identification

We propose a novel method for the task of protein subfamily identification; that is, finding subgroups of functionally closely related sequences within a protein family. In line with phylogenomic analysis, the method first builds a hierarchical tree using as input a multiple alignment of the protein...

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Bibliographic Details
Main Authors: Eduardo P. Costa, Celine Vens, Hendrik Blockeel
Format: Article
Language:English
Published: SAGE Publishing 2013-01-01
Series:Evolutionary Bioinformatics
Online Access:https://doi.org/10.4137/EBO.S11609