FcγR-TLR Cross-Talk Enhances TNF Production by Human Monocyte-Derived DCs via IRF5-Dependent Gene Transcription and Glycolytic Reprogramming

FcγR-TLR Cross-Talk Enhances TNF Production by Human Monocyte-Derived DCs via IRF5-Dependent Gene Transcription and Glycolytic Reprogramming

Antigen-presenting cells (APCs) such as dendritic cells (DCs) are crucial for initiation of adequate inflammatory responses, which critically depends on the cooperated engagement of different receptors. In addition to pattern recognition receptors (PRRs), Fc gamma receptors (FcγRs) have recently bee...

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Bibliographic Details
Main Authors: Willianne Hoepel, Melissa Newling, Lisa T. C. Vogelpoel, Lathees Sritharan, Ivo S. Hansen, Martien L. Kapsenberg, Dominique L. P. Baeten, Bart Everts, Jeroen den Dunnen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
Fc gamma receptor (FcγR)
interferon regulatory factor 5 (IRF5)
dendritic cells
macrophages
glycolytic reprogramming
tumor necrosis factor (TNF)
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00739/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00739/full

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