Activation-induced cell death of dendritic cells is dependent on sphingosine kinase 1

Activation-induced cell death of dendritic cells is dependent on sphingosine kinase 1

Sphingosine 1-phosphate (S1P) is an immune modulatory lipid mediator and has been implicated in numerous pathophysiological processes. S1P is produced by sphingosine kinase 1 (Sphk1) and Sphk2. Dendritic cells (DCs) are central for the direction of immune responses and crucially involved in autoimmu...

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Bibliographic Details
Main Authors: Anja eSchwiebs, Olga eFriesen, Elisabeth eKatzy, Nerea eFerreirós Bouzas, Josef M Pfeilschifter, Heinfried H. Radeke
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Pharmacology
Subjects:
Autoimmunity
Dendritic Cells
AICD
stat3
fingolimod
sphingosine 1-phosphate
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00094/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00094/full

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