PI3Kgamma Inhibitor Attenuates Immunosuppressive Effect of Poly(l‐Glutamic Acid)‐Combretastatin A4 Conjugate in Metastatic Breast Cancer

PI3Kgamma Inhibitor Attenuates Immunosuppressive Effect of Poly(l‐Glutamic Acid)‐Combretastatin A4 Conjugate in Metastatic Breast Cancer

Abstract Vascular disrupting agents (VDAs) have great potential for cancer treatment. Poly(l‐glutamic acid)‐combretastatin A4 conjugate (PLG‐CA4) is a novel class of VDAs. Though it has notable antitumor activity, it can induce host immune responses that promote tumor growth. Here, PLG‐CA4 induces t...

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Bibliographic Details
Main Authors: Hanjiao Qin, Haiyang Yu, Jiyao Sheng, Dawei Zhang, Na Shen, Linlin Liu, Zhaohui Tang, Xuesi Chen
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Advanced Science
Subjects:
combretastatin A4
immunotherapy
nanomedicine
tumor‐associated macrophages
vascular disrupting agents
Online Access:https://doi.org/10.1002/advs.201900327

Internet

https://doi.org/10.1002/advs.201900327

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