Multiple system atrophy: α-Synuclein strains at the neuron-oligodendrocyte crossroad

Multiple system atrophy: α-Synuclein strains at the neuron-oligodendrocyte crossroad

Abstract The aberrant accumulation of α-Synuclein within oligodendrocytes is an enigmatic, pathological feature specific to Multiple system atrophy (MSA). Since the characterization of the disease in 1969, decades of research have focused on unravelling the pathogenic processes that lead to the form...

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Bibliographic Details
Main Authors: Kreesan Reddy, Birger Victor Dieriks
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Molecular Neurodegeneration
Subjects:
Multiple system atrophy
Alpha-synuclein
Synucleinopathy
Protein aggregation
Oligodendroglial proteinopathy
Glial cytoplasmic inclusion
Online Access:https://doi.org/10.1186/s13024-022-00579-z

Internet

https://doi.org/10.1186/s13024-022-00579-z

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