Cabozantinib Is Effective in Melanoma Brain Metastasis Cell Lines and Affects Key Signaling Pathways

Cabozantinib Is Effective in Melanoma Brain Metastasis Cell Lines and Affects Key Signaling Pathways

Melanomas have a high potential to metastasize to the brain. Recent advances in targeted therapies and immunotherapies have changed the therapeutical landscape of extracranial melanomas. However, few patients with melanoma brain metastasis (MBM) respond effectively to these treatments and new therap...

Full description

Bibliographic Details
Main Authors: Trond Are Mannsåker, Tuyen Hoang, Synnøve Nymark Aasen, Ole Vidhammer Bjørnstad, Himalaya Parajuli, Terje Sundstrøm, Frits Alan Thorsen
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
brain metastasis
melanoma
cabozantinib
apoptosis
PDGF-Rα
IGF-1R
Online Access:https://www.mdpi.com/1422-0067/22/22/12296

Internet

https://www.mdpi.com/1422-0067/22/22/12296

Similar Items