Design, synthesis, and molecular dynamics simulation studies of some novel kojic acid fused 2-amino-3-cyano-4H-pyran derivatives as tyrosinase inhibitors

Design, synthesis, and molecular dynamics simulation studies of some novel kojic acid fused 2-amino-3-cyano-4H-pyran derivatives as tyrosinase inhibitors

Abstract A novel series of kojic acid fused 2-amino-3-cyano-4H-pyran derivatives were synthesized via a multicomponent reaction involving kojic acid, benzyloxy benzaldehyde, and malonitrile as tyrosinase inhibitors. Subsequently, the structures of the compounds were characterized using FT-IR, 1H-, a...

Full description

Bibliographic Details
Main Authors: Zahra Najafi, Maryam Zandi Haramabadi, Gholamabbas Chehardoli, Ahmad Ebadi‬, Aida Iraji
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Chemistry
Subjects:
Kojic acid
Benzyloxy benzylidene
2-Amino-3-cyano-4H-pyran
Molecular dynamics simulation
Tyrosinase inhibitors
Online Access:https://doi.org/10.1186/s13065-024-01134-1

Internet

https://doi.org/10.1186/s13065-024-01134-1

Similar Items