Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors

Synthesis and analytical characterization of new thiazol-2-(3H)-ones as human neutrophil elastase (HNE) inhibitors

Abstract Human neutrophil elastase (HNE) is a potent serine protease belonging to the chymotrypsin family and is involved in a variety of pathologies affecting the respiratory system. Thus, compounds able to inhibit HNE proteolytic activity could represent effective therapeutics. We present here the...

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Bibliographic Details
Main Authors: Letizia Crocetti, Gianluca Bartolucci, Agostino Cilibrizzi, Maria Paola Giovannoni, Gabriella Guerrini, Antonella Iacovone, Marta Menicatti, Igor A. Schepetkin, Andrei I. Khlebnikov, Mark T. Quinn, Claudia Vergelli
Format: Article
Language:English
Published: BMC 2017-12-01
Series:Chemistry Central Journal
Subjects:
Thiazol-2-(3H)-one
Synthesis
LC–MS/MS
ERMS
Human neutrophil elastase
Online Access:http://link.springer.com/article/10.1186/s13065-017-0358-1

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http://link.springer.com/article/10.1186/s13065-017-0358-1

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