Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration

Amyloid precursor proteins are protective in Drosophila models of progressive neurodegeneration

The processing of Amyloid Precursor Proteins (APPs) results in several fragments, including soluble N-terminal ectodomains (sAPPs) and C-terminal intracellular domains (AICD). sAPPs have been ascribed neurotrophic or neuroprotective functions in cell culture, although β-cleaved sAPPs can have delete...

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Bibliographic Details
Main Authors: Jill S. Wentzell, Bonnie J. Bolkan, Katia Carmine-Simmen, Tracy L. Swanson, Derek T. Musashe, Doris Kretzschmar
Format: Article
Language:English
Published: Elsevier 2012-04-01
Series:Neurobiology of Disease
Subjects:
APP
APPL
Neuroprotection
Neurodegeneration
Drosophila
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112000022

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http://www.sciencedirect.com/science/article/pii/S0969996112000022

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