Computational insights into the stereo-selectivity of catechins for the inhibition of the cancer therapeutic target EGFR kinase

Computational insights into the stereo-selectivity of catechins for the inhibition of the cancer therapeutic target EGFR kinase

The epidermal growth factor receptor (EGFR) plays a crucial role in regulating cellular growth and survival, and its dysregulation is implicated in various cancers, making it a prime target for cancer therapy. Natural compounds known as catechins have garnered attention as promising anticancer agent...

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Bibliographic Details
Main Authors: Mohd Rehan, Firoz Ahmed, Mohammad Imran Khan, Hifzur Rahman Ansari, Shazi Shakil, Moustafa E. El-Araby, Salman Hosawi, Mohammad Saleem
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Pharmacology
Subjects:
EGCG
gallocatechin
gallocatechin gallate
small molecules
kinases
spatial isomers
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1231671/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1231671/full

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