The Role of GLI in the Regulation of Hepatic Epithelial–Mesenchymal Transition in Biliary Atresia

The Role of GLI in the Regulation of Hepatic Epithelial–Mesenchymal Transition in Biliary Atresia

ObjectiveTo study the regulatory role of GLI1/GLI2, a nuclear transcription factor of the Sonic hedgehog (Shh) signaling pathway, in epithelial–mesenchymal transition (EMT) related to hepatic fibrosis in patients with biliary atresia (BA).MethodsThe messenger RNA (mRNA) and protein expression levels...

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Bibliographic Details
Main Authors: Pu Siyu, Wang Junxiang, Wang Qi, Zhang Yimao, Jin Shuguang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pediatrics
Subjects:
biliary atresia
epithelial–mesenchymal transition
Shh signaling pathway
GLI
liver fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fped.2022.861826/full

Internet

https://www.frontiersin.org/articles/10.3389/fped.2022.861826/full

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