Small interfering RNA-mediated suppression of Ccl2 in Müller cells attenuates microglial recruitment and photoreceptor death following retinal degeneration

<p>Abstract</p> <p>Background</p> <p>The recruitment and activation of inflammatory cells is thought to exacerbate photoreceptor death in retinal degenerative conditions such as age-related macular degeneration (AMD). We investigated the role of Müller cell-derived chem...

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Bibliographic Details
Main Authors: Rutar Matt, Natoli Riccardo, Provis Jan M
Format: Article
Language:English
Published: BMC 2012-09-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/9/1/221