The Effect of Hyaluronic Acid Gel on Periodontal Parameters, Pro-Inflammatory Cytokines and Biochemical Markers in Periodontitis Patients
Hyaluronic acid in its various forms shows bacteriostatic, fungistatic, anti-inflammatory, anti-edematous, osteoinductive, and pro-angiogenetic properties. This study aimed to evaluate the effect of subgingival delivery of 0.8% hyaluronic acid (HA) gel on clinical periodontal parameters, pro-inflamm...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Gels |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2310-2861/9/4/325 |
| _version_ | 1827744994717335552 |
|---|---|
| author | Chenar Anwar Mohammad Barzan Abdulwahab Mirza Zainab Salim Mahmood Faraedon Mostafa Zardawi |
| author_facet | Chenar Anwar Mohammad Barzan Abdulwahab Mirza Zainab Salim Mahmood Faraedon Mostafa Zardawi |
| author_sort | Chenar Anwar Mohammad |
| collection | DOAJ |
| description | Hyaluronic acid in its various forms shows bacteriostatic, fungistatic, anti-inflammatory, anti-edematous, osteoinductive, and pro-angiogenetic properties. This study aimed to evaluate the effect of subgingival delivery of 0.8% hyaluronic acid (HA) gel on clinical periodontal parameters, pro-inflammatory cytokines (IL-1 beta and TNF-alpha) and biochemical markers of inflammation (C-reactive protein (CRP) and alkaline phosphatase (ALP) enzymes) in patients with periodontitis. Seventy-five patients with chronic periodontitis were divided randomly into three groups (25 in each group): group I received scaling and surface root debridement (SRD) + HA gel; group II received SRD + chlorhexidine gel; and group III received surface root debridement alone. Clinical periodontal parameter measurements and blood samples were collected to estimate pro-inflammatory and biochemical parameters at the baseline before therapy and after two months of therapy. The results show that HA gel has a significant effect on the reduction in clinical periodontal parameters (PI, GI, BOP, PPD, and CAL), IL-1 beta, TNF-alpha, CRP, and ALP after 2 months of therapy as compared to the baseline (<i>p</i> < 0.05) with nonsignificant differences from the CHX group (<i>p</i> > 0.05), except GI (<i>p</i> < 0.05), and significant differences from the SRD group (<i>p</i> < 0.05). Moreover, significant differences were found between the three groups regarding the mean improvements of GI, BOP, PPD, IL-1β, CRP, and ALP. It can be concluded that HA gel has a positive effect on clinical periodontal parameters and improvements in inflammatory mediators similar to chlorhexidine. Therefore, HA gel can be used as an adjuvant to SRD in the treatment of periodontitis. |
| first_indexed | 2024-03-11T04:59:51Z |
| format | Article |
| id | doaj.art-330b0bbb270c4a66aee248fd4d398aa8 |
| institution | Directory Open Access Journal |
| issn | 2310-2861 |
| language | English |
| last_indexed | 2024-03-11T04:59:51Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj.art-330b0bbb270c4a66aee248fd4d398aa82023-11-17T19:21:51ZengMDPI AGGels2310-28612023-04-019432510.3390/gels9040325The Effect of Hyaluronic Acid Gel on Periodontal Parameters, Pro-Inflammatory Cytokines and Biochemical Markers in Periodontitis PatientsChenar Anwar Mohammad0Barzan Abdulwahab Mirza1Zainab Salim Mahmood2Faraedon Mostafa Zardawi3Periodontics Department, College of Dentistry, Hawler Medical University, Erbil 44001, IraqPeriodontics Department, College of Dentistry, Hawler Medical University, Erbil 44001, IraqPeriodontics Department, College of Dentistry, Hawler Medical University, Erbil 44001, IraqDean of Faculty of Dentistry, Qaiwan International University, Sulaimani 00964, IraqHyaluronic acid in its various forms shows bacteriostatic, fungistatic, anti-inflammatory, anti-edematous, osteoinductive, and pro-angiogenetic properties. This study aimed to evaluate the effect of subgingival delivery of 0.8% hyaluronic acid (HA) gel on clinical periodontal parameters, pro-inflammatory cytokines (IL-1 beta and TNF-alpha) and biochemical markers of inflammation (C-reactive protein (CRP) and alkaline phosphatase (ALP) enzymes) in patients with periodontitis. Seventy-five patients with chronic periodontitis were divided randomly into three groups (25 in each group): group I received scaling and surface root debridement (SRD) + HA gel; group II received SRD + chlorhexidine gel; and group III received surface root debridement alone. Clinical periodontal parameter measurements and blood samples were collected to estimate pro-inflammatory and biochemical parameters at the baseline before therapy and after two months of therapy. The results show that HA gel has a significant effect on the reduction in clinical periodontal parameters (PI, GI, BOP, PPD, and CAL), IL-1 beta, TNF-alpha, CRP, and ALP after 2 months of therapy as compared to the baseline (<i>p</i> < 0.05) with nonsignificant differences from the CHX group (<i>p</i> > 0.05), except GI (<i>p</i> < 0.05), and significant differences from the SRD group (<i>p</i> < 0.05). Moreover, significant differences were found between the three groups regarding the mean improvements of GI, BOP, PPD, IL-1β, CRP, and ALP. It can be concluded that HA gel has a positive effect on clinical periodontal parameters and improvements in inflammatory mediators similar to chlorhexidine. Therefore, HA gel can be used as an adjuvant to SRD in the treatment of periodontitis.https://www.mdpi.com/2310-2861/9/4/325biomedical markershyaluronic acid gelperiodontitiscytokines |
| spellingShingle | Chenar Anwar Mohammad Barzan Abdulwahab Mirza Zainab Salim Mahmood Faraedon Mostafa Zardawi The Effect of Hyaluronic Acid Gel on Periodontal Parameters, Pro-Inflammatory Cytokines and Biochemical Markers in Periodontitis Patients Gels biomedical markers hyaluronic acid gel periodontitis cytokines |
| title | The Effect of Hyaluronic Acid Gel on Periodontal Parameters, Pro-Inflammatory Cytokines and Biochemical Markers in Periodontitis Patients |
| title_full | The Effect of Hyaluronic Acid Gel on Periodontal Parameters, Pro-Inflammatory Cytokines and Biochemical Markers in Periodontitis Patients |
| title_fullStr | The Effect of Hyaluronic Acid Gel on Periodontal Parameters, Pro-Inflammatory Cytokines and Biochemical Markers in Periodontitis Patients |
| title_full_unstemmed | The Effect of Hyaluronic Acid Gel on Periodontal Parameters, Pro-Inflammatory Cytokines and Biochemical Markers in Periodontitis Patients |
| title_short | The Effect of Hyaluronic Acid Gel on Periodontal Parameters, Pro-Inflammatory Cytokines and Biochemical Markers in Periodontitis Patients |
| title_sort | effect of hyaluronic acid gel on periodontal parameters pro inflammatory cytokines and biochemical markers in periodontitis patients |
| topic | biomedical markers hyaluronic acid gel periodontitis cytokines |
| url | https://www.mdpi.com/2310-2861/9/4/325 |
| work_keys_str_mv | AT chenaranwarmohammad theeffectofhyaluronicacidgelonperiodontalparametersproinflammatorycytokinesandbiochemicalmarkersinperiodontitispatients AT barzanabdulwahabmirza theeffectofhyaluronicacidgelonperiodontalparametersproinflammatorycytokinesandbiochemicalmarkersinperiodontitispatients AT zainabsalimmahmood theeffectofhyaluronicacidgelonperiodontalparametersproinflammatorycytokinesandbiochemicalmarkersinperiodontitispatients AT faraedonmostafazardawi theeffectofhyaluronicacidgelonperiodontalparametersproinflammatorycytokinesandbiochemicalmarkersinperiodontitispatients AT chenaranwarmohammad effectofhyaluronicacidgelonperiodontalparametersproinflammatorycytokinesandbiochemicalmarkersinperiodontitispatients AT barzanabdulwahabmirza effectofhyaluronicacidgelonperiodontalparametersproinflammatorycytokinesandbiochemicalmarkersinperiodontitispatients AT zainabsalimmahmood effectofhyaluronicacidgelonperiodontalparametersproinflammatorycytokinesandbiochemicalmarkersinperiodontitispatients AT faraedonmostafazardawi effectofhyaluronicacidgelonperiodontalparametersproinflammatorycytokinesandbiochemicalmarkersinperiodontitispatients |