A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein

A neutralizing single-domain antibody that targets the trimer interface of the human metapneumovirus fusion protein

ABSTRACTHuman metapneumovirus (hMPV) is a leading cause of viral lower respiratory tract disease in children and adults. The hMPV fusion protein F is a trimeric class I fusion protein that is initially synthesized as a precursor (F0) and requires proteolytic activation by a host cell protease to gen...

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Bibliographic Details
Main Authors: Marlies Ballegeer, Revina C. van Scherpenzeel, Teresa Delgado, Maria Iglesias-Caballero, Blanca García Barreno, Shubham Pandey, Scott A. Rush, Joost A. Kolkman, Vicente Mas, Jason S. McLellan, Xavier Saelens
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mBio
Subjects:
human metapneumovirus
single-domain antibody
fusion protein
structure
Online Access:https://journals.asm.org/doi/10.1128/mbio.02122-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02122-23

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