Sequential targeting of interferon pathways for increased host resistance to bacterial superinfection during influenza.

Sequential targeting of interferon pathways for increased host resistance to bacterial superinfection during influenza.

Bacterial co-infections represent a major clinical complication of influenza. Host-derived interferon (IFN) increases susceptibility to bacterial infections following influenza, but the relative roles of type-I versus type-II IFN remain poorly understood. We have used novel mouse models of co-infect...

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Bibliographic Details
Main Authors: Tarani Kanta Barman, Rachael Racine, Jesse L Bonin, Danielle Califano, Sharon L Salmon, Dennis W Metzger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-03-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009405

Internet

https://doi.org/10.1371/journal.ppat.1009405

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