A LTB4/CD11b self-amplifying loop drives pyogranuloma formation in chronic granulomatous disease

A LTB4/CD11b self-amplifying loop drives pyogranuloma formation in chronic granulomatous disease

Summary: Sterile pyogranulomas and heightened cytokine production are hyperinflammatory hallmarks of Chronic Granulomatous Disease (CGD). Using peritoneal cells of zymosan-treated CGD (gp91phox−/−) versus wild-type (WT) mice, an ex vivo system of pyogranuloma formation was developed to determine fac...

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Bibliographic Details
Main Authors: Kelsey C. Haist, Sophie L. Gibbings, Jordan Jacobelli, Kara J. Mould, Peter M. Henson, Donna L. Bratton
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Natural sciences
Biological sciences
Physiology
Pathophysiology
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224008113

Internet

http://www.sciencedirect.com/science/article/pii/S2589004224008113

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