mRNA vaccine trafficking and resulting protein expression after intramuscular administration

mRNA vaccine trafficking and resulting protein expression after intramuscular administration

The mRNA vaccine route from injection site to critical immunologic tissues, as well as the localization of protein antigen following intramuscular (i.m.) administration, is crucial to generating an effective immune response. Here, we quantified mRNA at the injection site, lymph nodes, and in select...

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Bibliographic Details
Main Authors: Kimberly J. Hassett, Ivana Liric Rajlic, Kapil Bahl, Rebecca White, Kristen Cowens, Eric Jacquinet, Kristine E. Burke
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
lipid nanoparticles
mRNA
vaccine
intramuscular
delivery
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123003013

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http://www.sciencedirect.com/science/article/pii/S2162253123003013

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