Vaccination with a combination of STING agonist-loaded lipid nanoparticles and CpG-ODNs protects against lung metastasis via the induction of CD11bhighCD27low memory-like NK cells

Vaccination with a combination of STING agonist-loaded lipid nanoparticles and CpG-ODNs protects against lung metastasis via the induction of CD11bhighCD27low memory-like NK cells

Abstract Background Natural killer (NK) cells are effective in attacking tumor cells that escape T cell attack. Memory NK cells are believed to function as potent effector cells in cancer immunotherapy. However, knowledge of their induction, identification, and potential in vivo is limited. Herein,...

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Bibliographic Details
Main Authors: Alaa M. Khalifa, Takashi Nakamura, Yusuke Sato, Hideyoshi Harashima
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Experimental Hematology & Oncology
Subjects:
STING agonist
CpG-ODN
CD11bhighCD27low memory-like NK cells
Prophylactic cancer vaccine
Drug delivery system
Online Access:https://doi.org/10.1186/s40164-024-00502-w

Internet

https://doi.org/10.1186/s40164-024-00502-w

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