Low-dose brain irradiation normalizes TSPO and CLUSTERIN levels and promotes the non-amyloidogenic pathway in pre-symptomatic TgF344-AD rats

Low-dose brain irradiation normalizes TSPO and CLUSTERIN levels and promotes the non-amyloidogenic pathway in pre-symptomatic TgF344-AD rats

Abstract Preclinical studies have recently evaluated the impact of low-dose brain radiation therapy (LD-RT) in animal models of Alzheimer’s disease (AD) showing anti-amyloid and anti-inflammatory effects of this treatment. Its effectiveness varied, however, depending on the LD-RT protocol used and t...

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Bibliographic Details
Main Authors: Kelly Ceyzériat, Thomas Zilli, Philippe Millet, Nikolaos Koutsouvelis, Giovanna Dipasquale, Christine Fossey, Thomas Cailly, Frédéric Fabis, Giovanni B. Frisoni, Valentina Garibotto, Benjamin B. Tournier
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Neuroinflammation
Subjects:
Radiotherapy
Alzheimer’s disease
Neuroinflammation
Amyloid
Low-dose
Online Access:https://doi.org/10.1186/s12974-022-02673-x

Internet

https://doi.org/10.1186/s12974-022-02673-x

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