Identification of an Immature Subset of PMN-MDSC Correlated to Response to Checkpoint Inhibitor Therapy in Patients with Metastatic Melanoma

Identification of an Immature Subset of PMN-MDSC Correlated to Response to Checkpoint Inhibitor Therapy in Patients with Metastatic Melanoma

PMN-MDSCs support tumor progression and resistance to ICI therapy through their suppressive functions but their heterogeneity limits their use as biomarkers in cancer. Our aim was to investigate the phenotypic and functional subsets of PMN-MDSCs to identify biomarkers of response to ICI therapy. We...

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Bibliographic Details
Main Authors: Françoise Gondois-Rey, Magali Paul, Florence Alcaraz, Sarah Bourass, Jilliana Monnier, Nausicaa Malissen, Jean-Jacques Grob, Annika M. Bruger, Pierre Van Der Bruggen, Caroline Gaudy-Marqueste, Daniel Olive
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
PMN-MDSC
immune suppression
metastatic melanoma
immune-checkpoint therapy
signal regulatory protein alpha
Online Access:https://www.mdpi.com/2072-6694/13/6/1362

Internet

https://www.mdpi.com/2072-6694/13/6/1362

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