Multimodal Mass Spectrometry Imaging of an Osteosarcoma Multicellular Tumour Spheroid Model to Investigate Drug-Induced Response

Multimodal Mass Spectrometry Imaging of an Osteosarcoma Multicellular Tumour Spheroid Model to Investigate Drug-Induced Response

A multimodal mass spectrometry imaging (MSI) approach was used to investigate the chemotherapy drug-induced response of a Multicellular Tumour Spheroid (MCTS) 3D cell culture model of osteosarcoma (OS). The work addresses the critical demand for enhanced translatable early drug discovery approaches...

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Bibliographic Details
Main Authors: Sophie M. Pearce, Neil A. Cross, David P. Smith, Malcolm R. Clench, Lucy E. Flint, Gregory Hamm, Richard Goodwin, James I. Langridge, Emmanuelle Claude, Laura M. Cole
Format: Article
Language:English
Published: MDPI AG 2024-05-01
Series:Metabolites
Subjects:
chemotherapy
mass spectrometry imaging
DESI-MSI
MALDI-IHC
imaging mass cytometry
doxorubicin
Online Access:https://www.mdpi.com/2218-1989/14/6/315

Internet

https://www.mdpi.com/2218-1989/14/6/315

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