Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs

Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs

Abstract A variety of base editors have been developed to achieve C-to-T editing in different genomic contexts. Here, we compare a panel of five base editors on their C-to-T editing efficiencies and product purity at commonly editable sites, including some human pathogenic C-to-T mutations. We furth...

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Bibliographic Details
Main Authors: Ying Wang, Runze Gao, Jing Wu, Yi-Chun Xiong, Jia Wei, Sipin Zhang, Bei Yang, Jia Chen, Li Yang
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Genome Biology
Subjects:
Base editing
Base editor
CRISPR/Cas
Cytidine deaminase
Pathogenic mutation
Online Access:http://link.springer.com/article/10.1186/s13059-019-1839-4

Internet

http://link.springer.com/article/10.1186/s13059-019-1839-4

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