The Effect of Fluid Flow Shear Stress and Substrate Stiffness on Yes-Associated Protein (YAP) Activity and Osteogenesis in Murine Osteosarcoma Cells

The Effect of Fluid Flow Shear Stress and Substrate Stiffness on Yes-Associated Protein (YAP) Activity and Osteogenesis in Murine Osteosarcoma Cells

Osteosarcoma (OS) is an aggressive bone cancer originating in the mesenchymal lineage. Prognosis for metastatic disease is poor, with a mortality rate of approximately 40%; OS is an aggressive disease for which new treatments are needed. All bone cells are sensitive to their mechanical/physical surr...

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Bibliographic Details
Main Authors: Thomas R. Coughlin, Ali Sana, Kevin Voss, Abhilash Gadi, Upal Basu-Roy, Caroline M. Curtin, Alka Mansukhani, Oran D. Kennedy
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
osteosarcoma
mechanobiology
osteogenesis
shear stress
substrate stiffness
Online Access:https://www.mdpi.com/2072-6694/13/13/3128

Internet

https://www.mdpi.com/2072-6694/13/13/3128

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