In mouse chronic pancreatitis CD25+FOXP3+ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response

In mouse chronic pancreatitis CD25+FOXP3+ regulatory T cells control pancreatic fibrosis by suppression of the type 2 immune response

The function of T regulatory cells in the tissue fibrosis in chronic pancreatitis is not fully understood. Here the authors use a mouse model of chronic pancreatitis to show that Treg cells reduce IL-4 mediated chronic inflammation in the pancreas associated with M2-like macrophages in vivo.

Bibliographic Details
Main Authors: Juliane Glaubitz, Anika Wilden, Janine Golchert, Georg Homuth, Uwe Völker, Barbara M. Bröker, Thomas Thiele, Markus M. Lerch, Julia Mayerle, Ali A. Aghdassi, Frank U. Weiss, Matthias Sendler
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32195-2

Internet

https://doi.org/10.1038/s41467-022-32195-2

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