Glutamine Produces Ammonium to Tune Lysosomal pH and Regulate Lysosomal Function

Glutamine Produces Ammonium to Tune Lysosomal pH and Regulate Lysosomal Function

Glutamine is one of the most abundant amino acids in the cell. In mitochondria, glutaminases 1 and 2 (GLS1/2) hydrolyze glutamine to glutamate, which serves as the precursor of multiple metabolites. Here, we show that ammonium generated during GLS1/2-mediated glutaminolysis regulates lysosomal pH an...

Full description

Bibliographic Details
Main Authors: Jian Xiong, Thi Thu Trang Luu, Kartik Venkatachalam, Guangwei Du, Michael X. Zhu
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
amino acid starvation
autophagy
autophagosome
glutaminase
glutamine
lysosomal pH
Online Access:https://www.mdpi.com/2073-4409/12/1/80

Internet

https://www.mdpi.com/2073-4409/12/1/80

Similar Items