Mesenchymal Stem Cells and NF-κB Sensing Interleukin-4 Over-Expressing Mesenchymal Stem Cells Are Equally Effective in Mitigating Particle-Associated Chronic Inflammatory Bone Loss in Mice

Mesenchymal Stem Cells and NF-κB Sensing Interleukin-4 Over-Expressing Mesenchymal Stem Cells Are Equally Effective in Mitigating Particle-Associated Chronic Inflammatory Bone Loss in Mice

Wear particles from total joint arthroplasties (TJAs) induce chronic inflammation, macrophage infiltration and lead to bone loss by promoting bone destruction and inhibiting bone formation. Inhibition of particle-associated chronic inflammation and the associated bone loss is critical to the success...

Full description

Bibliographic Details
Main Authors: Ning Zhang, Takeshi Utsunomiya, Tzuhua Lin, Yusuke Kohno, Masaya Ueno, Masahiro Maruyama, Ejun Huang, Claire Rhee, Zhenyu Yao, Stuart B. Goodman
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
wear particles
chronic inflammation
bone loss
mesenchymal stem cells
macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.757830/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.757830/full

Similar Items