Genetic variants of HIF1α are associated with right ventricular fibrotic load in repaired tetralogy of Fallot patients: a cardiovascular magnetic resonance study

Genetic variants of HIF1α are associated with right ventricular fibrotic load in repaired tetralogy of Fallot patients: a cardiovascular magnetic resonance study

Abstract Background Studies suggest that right ventricular (RV) fibrosis is associated with RV remodeling and long-term outcomes in patients with tetralogy of Fallot (TOF). Pre-operative hypoxia may increase expression of hypoxia inducible factor-1-alpha (HIF1α) and promote transforming growth facto...

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Bibliographic Details
Main Authors: Thanh T. Hoang, Paulo Henrique Manso, Sharon Edman, Laura Mercer-Rosa, Laura E. Mitchell, Anshuman Sewda, Michael D. Swartz, Mark A. Fogel, A. J. Agopian, Elizabeth Goldmuntz
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Journal of Cardiovascular Magnetic Resonance
Subjects:
Cardiovascular magnetic resonance imaging
HIF1α
Tetralogy of Fallot
Fibrosis
Right ventricular ejection fraction
Right ventricular end-diastolic volume
Online Access:http://link.springer.com/article/10.1186/s12968-019-0555-2

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http://link.springer.com/article/10.1186/s12968-019-0555-2

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