Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis.

Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis.

Deletion of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) envelope (E) gene attenuates the virus. E gene encodes a small multifunctional protein that possesses ion channel (IC) activity, an important function in virus-host interaction. To test the contribution of E protein IC activity in...

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Bibliographic Details
Main Authors: Jose L Nieto-Torres, Marta L DeDiego, Carmina Verdiá-Báguena, Jose M Jimenez-Guardeño, Jose A Regla-Nava, Raul Fernandez-Delgado, Carlos Castaño-Rodriguez, Antonio Alcaraz, Jaume Torres, Vicente M Aguilella, Luis Enjuanes
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004077&type=printable

Internet

https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004077&type=printable

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