The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials

The miniaturized enzyme-modified comet assay for genotoxicity testing of nanomaterials

The in vitro comet assay is a widely applied method for investigating genotoxicity of chemicals including engineered nanomaterials (NMs). A big challenge in hazard assessment of NMs is possible interference between the NMs and reagents or read-out of the test assay, leading to a risk of biased resul...

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Bibliographic Details
Main Authors: N. El Yamani, E. Rundén-Pran, A. R. Collins, E. M. Longhin, E. Elje, P. Hoet, I. Vinković Vrček, S. H. Doak, V. Fessard, M. Dusinska
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Toxicology
Subjects:
alkaline comet assay
nanomaterial
genotoxicity
DNA damage
interference
lesion-specific endonucleases
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2022.986318/full

Internet

https://www.frontiersin.org/articles/10.3389/ftox.2022.986318/full

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