Effects of Ultramicronized <i>N</i>-Palmitoylethanolamine Supplementation on Tramadol and Oxycodone Analgesia and Tolerance Prevention

Effects of Ultramicronized <i>N</i>-Palmitoylethanolamine Supplementation on Tramadol and Oxycodone Analgesia and Tolerance Prevention

Chronic pain management requires increasing doses of opioids, the milestone of painkillers, which may result in the onset of tolerance with exacerbated side effects. Maintaining stable analgesia with low doses of opioids is thus imperative. <i>N</i>-palmitoylethanolamine (PEA) is an endo...

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Bibliographic Details
Main Authors: Laura Micheli, Elena Lucarini, Alessandra Toti, Valentina Ferrara, Clara Ciampi, Carmen Parisio, Gianluca Bartolucci, Lorenzo Di Cesare Mannelli, Carla Ghelardini
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Pharmaceutics
Subjects:
pain therapy
opioid
tolerance
astrocyte
PEA
tramadol
Online Access:https://www.mdpi.com/1999-4923/14/2/403

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https://www.mdpi.com/1999-4923/14/2/403

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