IL-17A signaling in colonic epithelial cells inhibits pro-inflammatory cytokine production by enhancing the activity of ERK and PI3K.

IL-17A signaling in colonic epithelial cells inhibits pro-inflammatory cytokine production by enhancing the activity of ERK and PI3K.

Our previous data suggested that IL-17A contributes to the inhibition of Th1 cell function in the gut. However, the underlying mechanisms remain unclear. Here we demonstrate that IL-17A signaling in colonic epithelial cells (CECs) increases TNF-α-induced PI3K-AKT and ERK phosphorylation and inhibits...

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Bibliographic Details
Main Authors: Xiaoqin Guo, Xingwei Jiang, Yan Xiao, Tingting Zhou, Yueling Guo, Renxi Wang, Zhi Zhao, He Xiao, Chunmei Hou, Lingyun Ma, Yanhua Lin, Xiaoling Lang, Jiannan Feng, Guojiang Chen, Beifen Shen, Gencheng Han, Yan Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3934915?pdf=render

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http://europepmc.org/articles/PMC3934915?pdf=render

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