Revisiting the Development of Vaccines Against Pathogenic Leptospira: Innovative Approaches, Present Challenges, and Future Perspectives

Human vaccination against leptospirosis has been relatively unsuccessful in clinical applications despite an expressive amount of vaccine candidates has been tested over years of research. Pathogenic Leptospira encompass a great number of serovars, most of which do not cross-react, and there has bee...

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Bibliographic Details
Main Authors: Giovana C. Barazzone, Aline F. Teixeira, Bruna O. P. Azevedo, Deborah K. Damiano, Marcos P. Oliveira, Ana L. T. O. Nascimento, Alexandre P. Y. Lopes
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.760291/full