Intrabiliary infusion of naked DNA vectors targets periportal hepatocytes in mice

Intrabiliary infusion of naked DNA vectors targets periportal hepatocytes in mice

Hydrodynamic tail vein injection (HTV) is the “gold standard” for delivering naked DNA vectors to mouse liver, thereby transfecting predominately perivenous hepatocytes. While HTV corrects metabolic liver defects such as phenylketonuria or cystathionine β-synthase deficiency, correction of spfash mi...

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Bibliographic Details
Main Authors: Sereina Deplazes, Andrea Schlegel, Zhuolun Song, Gabriella Allegri, Nicole Rimann, Tanja Scherer, Melanie Willimann, Lennart Opitz, Sharon C. Cunningham, Ian E. Alexander, Anja Kipar, Johannes Häberle, Beat Thöny, Hiu Man Grisch-Chan
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
hydrodynamic retrograde intrabiliary injection
liver-directed gene therapy
non-viral
naked DNA minicircle vector
urea cycle disorder
OTC deficiency
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050122001486

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http://www.sciencedirect.com/science/article/pii/S2329050122001486

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