Inducible miR-1224 silences cerebrovascular Serpine1 and restores blood flow to the stroke-affected site of the brain

Inducible miR-1224 silences cerebrovascular Serpine1 and restores blood flow to the stroke-affected site of the brain

The α-tocotrienol (TCT) form of natural vitamin E is more potent than the better known α-tocopherol against stroke. Angiographic studies of canine stroke have revealed beneficial cerebrovascular effects of TCT. This work seeks to understand the molecular basis of such effect. In mice, TCT supplement...

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Bibliographic Details
Main Authors: Ravichand Palakurti, Nirupam Biswas, Sashwati Roy, Surya C. Gnyawali, Mithun Sinha, Kanhaiya Singh, Subhadip Ghatak, Chandan K. Sen, Savita Khanna
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Noncoding RNAs
miR-1224
Serpine1
tocotrienol
stroke
MCAO
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253123000021

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http://www.sciencedirect.com/science/article/pii/S2162253123000021

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