Observations on the Changing Shape of the Ice Mass and the Determination of the Sublimation End Point in Freeze-Drying: An Application for Through-Vial Impedance Spectroscopy (TVIS)
Models for ice sublimation from a freeze-drying vial rely on the assumption of a planar ice interface up to ~25% loss of ice mass (which is difficult to qualify) whereas single-vial determinations of the sublimation endpoint (by temperature sensors) are based on the point when the observed temperatu...
| Main Authors: | , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
MDPI AG
2021-11-01
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| 丛编: | Pharmaceutics |
| 主题: | |
| 在线阅读: | https://www.mdpi.com/1999-4923/13/11/1835 |