Thrombomodulin in disseminated intravascular coagulation and other critical conditions—a multi-faceted anticoagulant protein with therapeutic potential

Thrombomodulin in disseminated intravascular coagulation and other critical conditions—a multi-faceted anticoagulant protein with therapeutic potential

Abstract Thrombomodulin plays a vital role in maintaining intravascular patency due to its anticoagulant, antiinflammatory, and cytoprotective properties. However, under pathological conditions such as sepsis and systemic inflammation, endothelial thrombomodulin expression is downregulated and its f...

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Bibliographic Details
Main Authors: Takashi Ito, Jecko Thachil, Hidesaku Asakura, Jerrold H. Levy, Toshiaki Iba
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Critical Care
Subjects:
Recombinant thrombomodulin
Disseminated intravascular coagulation (DIC)
Coagulopathy
Randomized controlled trial
Bleeding
Sepsis
Online Access:http://link.springer.com/article/10.1186/s13054-019-2552-0

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http://link.springer.com/article/10.1186/s13054-019-2552-0

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