Somatic mutations in four novel genes contribute to homologous recombination deficiency in breast cancer: a real‐world clinical tumor sequencing study

Somatic mutations in four novel genes contribute to homologous recombination deficiency in breast cancer: a real‐world clinical tumor sequencing study

Abstract Breast cancers involving mutations in homologous recombination (HR) genes, most commonly BRCA1 and BRCA2 (BRCA1/2), respond well to PARP inhibitors and platinum‐based chemotherapy. However, except for these specific HR genes, it is not clear which other mutations contribute to homologous re...

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Bibliographic Details
Main Authors: Yongsheng Huang, Yuntan Qiu, Linxiaoxiao Ding, Shuwei Ren, Yuanling Jiang, Jiahuan Luo, Jinghua Huang, Xinke Yin, Sha Fu, Jianli Zhao, Kaishun Hu, Jianwei Liao
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:The Journal of Pathology: Clinical Research
Subjects:
homologous recombination
next‐generation sequencing
breast cancer
Online Access:https://doi.org/10.1002/2056-4538.12367

Internet

https://doi.org/10.1002/2056-4538.12367

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