Ribociclib Inhibits P-gp-Mediated Multidrug Resistance in Human Epidermoid Carcinoma Cells

Ribociclib Inhibits P-gp-Mediated Multidrug Resistance in Human Epidermoid Carcinoma Cells

The efficacy of cancer chemotherapy can be attenuated or abrogated by multidrug resistance (MDR) in cancer cells. In this study, we determined the effect of the CDK4/6 inhibitor, ribociclib (or LEE011), on P-glycoprotein (P-gp)-mediated MDR in the human epidermoid carcinoma MDR cell line, KB-C2, whi...

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Bibliographic Details
Main Authors: Lei Zhang, Biwei Ye, Yunfeng Lin, Yi-Dong Li, Jing-Quan Wang, Zhuo Chen, Feng-Feng Ping, Zhe-Sheng Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
cancer
ribociclib-LEE011
multidrug resistance (MDR)
cyclin dependent kinases
CDKs 4 and 6
P-glycoprotein (ABCB1 protein)
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.867128/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.867128/full

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