CXCR2 specific endocytosis of immunomodulatory peptide LL-37 in human monocytes and formation of LL-37 positive large vesicles in differentiated monoosteophils

CXCR2 specific endocytosis of immunomodulatory peptide LL-37 in human monocytes and formation of LL-37 positive large vesicles in differentiated monoosteophils

Immunomodulatory peptide cathelicidin/LL-37 induces human monocyte differentiation into a novel bone repair cell, the monoosteophil. We now demonstrate that LL-37 is endocytosed by monocytes over a period of 6 days producing large (10 × 2 μm), specialized LL-37 and integrin α3 positive vesicles. CXC...

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Bibliographic Details
Main Authors: Zhifang Zhang, Keith Le, Deirdre La Placa, Brian Armstrong, Marcia M. Miller, John E. Shively
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Bone Reports
Subjects:
Monocytes
Monoosteophils
LL-37
Cathelicidin
Confocal microscopy
Electron microscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187219300439

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http://www.sciencedirect.com/science/article/pii/S2352187219300439

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