Nuclear export inhibition jumbles epithelial–mesenchymal states and gives rise to migratory disorder in healthy epithelia

Nuclear export inhibition jumbles epithelial–mesenchymal states and gives rise to migratory disorder in healthy epithelia

Dynamic nucleocytoplasmic transport of E-M factors regulates cellular E-M states; yet, it remains unknown how simultaneously trapping these factors affects epithelia at the macroscale. To explore this question, we performed nuclear export inhibition (NEI) via leptomycin B and Selinexor treatment, wh...

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Bibliographic Details
Main Authors: Carly M Krull, Haiyi Li, Amit Pathak
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-02-01
Series:eLife
Subjects:
epithelial cells
nuclear export
nucleocytoplasmic transport
epithelial–mesenchymal transition
EMT
mechanobiology
Online Access:https://elifesciences.org/articles/81048

Internet

https://elifesciences.org/articles/81048

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