Mucosal Vaccination with UV-Inactivated <i>Chlamydia suis</i> in Pre-Exposed Outbred Pigs Decreases Pathogen Load and Induces CD4 T-Cell Maturation into IFN-γ<sup>+</sup> Effector Memory Cells

Mucosal Vaccination with UV-Inactivated <i>Chlamydia suis</i> in Pre-Exposed Outbred Pigs Decreases Pathogen Load and Induces CD4 T-Cell Maturation into IFN-γ<sup>+</sup> Effector Memory Cells

<i>Chlamydia trachomatis</i> (<i>Ct</i>) infections are the most frequent bacterial sexually transmitted disease, and they can lead to ectopic pregnancy and infertility. Despite these detrimental long-term sequelae, a vaccine is not available. Success in preclinical animal st...

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Bibliographic Details
Main Authors: Amanda F. Amaral, Khondaker S. Rahman, Andrew R. Kick, Lizette M. Cortes, James Robertson, Bernhard Kaltenboeck, Volker Gerdts, Catherine M. O’Connell, Taylor B. Poston, Xiaojing Zheng, Chuwen Liu, Sam Y. Omesi, Toni Darville, Tobias Käser
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Vaccines
Subjects:
<i>chlamydia trachomatis</i>
<i>chlamydia suis</i>
large animal model
swine
translational research
vaccine development
Online Access:https://www.mdpi.com/2076-393X/8/3/353

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https://www.mdpi.com/2076-393X/8/3/353

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