Pimobendan Inhibits HBV Transcription and Replication by Suppressing HBV Promoters Activity

Current anti-HBV therapeutic strategy relies on interferon and nucleos(t)ide-type drugs with the limitation of functional cure, inducing hepatitis B surface antigen (HBsAg) loss in very few patients. Notably, the level of HBsAg has been established as an accurate indicator to evaluate the drug effic...

Full description

Bibliographic Details
Main Authors: Si-Yu Yuan, Hai-Bo Yu, Zhen Yang, Yi-Ping Qin, Ji-Hua Ren, Sheng-Tao Cheng, Fang Ren, Betty Yuen Kwan Law, Vincent Kam Wai Wong, Jerome P. L. Ng, Yu-Jiao Zhou, Xin He, Ming Tan, Zhen-Zhen Zhang, Juan Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.837115/full