Pimobendan Inhibits HBV Transcription and Replication by Suppressing HBV Promoters Activity

Pimobendan Inhibits HBV Transcription and Replication by Suppressing HBV Promoters Activity

Current anti-HBV therapeutic strategy relies on interferon and nucleos(t)ide-type drugs with the limitation of functional cure, inducing hepatitis B surface antigen (HBsAg) loss in very few patients. Notably, the level of HBsAg has been established as an accurate indicator to evaluate the drug effic...

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Bibliographic Details
Main Authors:	Si-Yu Yuan, Hai-Bo Yu, Zhen Yang, Yi-Ping Qin, Ji-Hua Ren, Sheng-Tao Cheng, Fang Ren, Betty Yuen Kwan Law, Vincent Kam Wai Wong, Jerome P. L. Ng, Yu-Jiao Zhou, Xin He, Ming Tan, Zhen-Zhen Zhang, Juan Chen
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-06-01
Series:	Frontiers in Pharmacology
Subjects:	hepatitis B virus HBsAg pimobendan anti-HBV agents drug repurposing
Online Access:	https://www.frontiersin.org/articles/10.3389/fphar.2022.837115/full

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